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Informed consent implications of diagnostic evaluations for dementia

Filed under: Alzheimers Disease — admin at 4:00 pm on Monday, April 30, 2007 Edit This

Informed consent implications of diagnostic evaluations for dementia
(No abstract is available for this citation)

Newsbriefs
(No abstract is available for this citation)

{alpha}-Synuclein aggregation in pathological aging and Alzheimer’s disease: The impact of {beta}-amyloid plaque level

In central nervous system diseases, abnormal aggregation of one protein is often associated with aggregation of other proteins. To begin to assess whether ß-amyloid (Aß) is associated with -synuclein (AS) aggregation [secondary Lewy body (LB) formation], we used immunohistochemical techniques to compare the amygdala of 11 subjects with pathological aging and 18 with Alzheimer’s disease. Overall, Aß-40 plaque level was greater in cases with secondary AS aggregates. Aß42 plaque level was not associated with AS aggregation. Aß-40 plaque levels cannot be ruled out as a factor involved in secondary LB formation.

ANNOUNCEMENTS.

Page: 68
DOI: 10.1097/01.wad.0000262612.32991.fb

Finding An Effective Alzheimer’s Treatment
Finding An Effective Alzheimer’s Treatment Finding an effective Alzheimer’s treatment is intricate because there are a lot of misconceptions about this aspect. First of all, there is no actual andquot;cureandquot; for Alzheimer’s disease. It is the onset of a lifetime of brain activity that generates […]

Book Review: The Story of My Father
(No abstract is available for this citation)

Create Your Own Alzheimer’s Support Group
How to Create Your Own Alzheimer’s Support Group Seeking an Alzheimer’s support group is essential for your health and emotional well being as a reliable caregiver of the patient. The stress of living with and caring for a family member who has a terminal brain disorder […]

Calendar
(No abstract is available for this citation)

Prevalence and clinical correlates of neuropsychiatric symptoms in dementia

The purpose of this research was to assess the frequency and severity of neuropsychiatric and behavioral symptoms and to examine the association between preexisting medical conditions and specific neuropsychiatric symptoms in demented individuals. We studied 211 demented subjects (87.7 percent male) who were participants in epidemiological studies of dementia. Using the Neuropsychiatric Inventory (NPI), we assessed the frequency and severity of neuropsychiatric symptoms. We collected medical history information during a structured telephone interview. Our analyses focused on determining prevalence of neuropsychiatric symptoms by dementia diagnosis and severity. We also examined the association of history of head injury, alcohol abuse, and stroke with development of neuropsychiatric symptoms.

We found that neuropsychiatric symptoms were common, with approximately three-fourths of the subjects exhibiting at least one symptom during the preceding month. Apathy (39.3 percent), agitation (31.8 percent), and aberrant motor behavior (31.1 percent) were the most frequent symptoms. Frequency and severity of symptoms were similar for the all-dementia and

Alzheimer’s disease–only groups. neuropsychiatric symptoms varied by severity of dementia, but generally not in a consistent ordinal pattern. History of alcohol abuse, head injury, or stroke was associated with presence of specific neuropsychiatric symptoms in dementia.

While psychiatric symptoms are common in dementia, they also vary by type and severity of dementia. The finding that certain medical conditions may increase risk for specific types of neuropsychiatric symptoms expands our knowledge of the natural history of dementia and should improve management of dementia in medically ill patients. Our results may also shed light on mechanisms that underlie neuropsychiatric symptoms.

Alzheimer’s Test: What to Look For
Alzheimer’s Test: What to Look For Alzheimer’s disease is a degenerative brain disorder that causes a person to lose their memory, behave in ways they wouldn’t normally behave, and prevents its sufferers from thinking clearly. Since so many people suffer from the disease, an Alzheimer’s test should be conducted on […]

Wandering Behavior and Alzheimer Disease. The REAL.FR Prospective Study.

Page: 31
DOI: 10.1097/WAD.0b013e31802f243e
Authors: Rolland, Yves MD, PhD * + ++ [S]; Andrieu, Sandrine MD, PhD +; Cantet, Christelle MS +; Morley, John E. MD ++ [S]; Thomas, David MD ++ [S]; Nourhashemi, Fati MD, PhD * +; Vellas, Bruno MD, PhD * +; the REAL.FR Group

Alzheimer’s disease behaviors from past self-identities: An exploration of the memory and cognitive features

Alzheimer’s disease (AD) patients have been reported by caregivers to display “behaviors from past self-identities” (BPSI); however, there is little known about these distinct behaviors. This study, the first to explore BPSI, hypothesized that BPSI were associated with self-memory and cognitive impairments. Its purpose was to determine if AD subjects with and without BPSI differed on measures of autobiographical memory, selective attention, and fluency. The cross-sectional design compared 35 moderatestage AD subjects from an AD research center. Subjects demonstrating BPSI (37 percent) recalled significantly fewer recent autobiographical memories than AD subjects without BPSI. The results establish BPSI as a common behavior among moderate-stage AD patients and suggest that paucity of recent self-memories contributes to BPSI.

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